학과 정기세미나 안내

■ 제목Shining light on depressed brain: optogenetic rescue of depression in mice

■ 연사 : 김대수 교수 (KAIST 생명과학과)


■ 초청자 : 이건재 교수

■ 일시 : 4 19 () 16:00 

■ 장소 : 응용공학동 (W1) 1층 영상강의실

Abstract :


In brain disorders, the functional alteration of neural circuits leads to emotional and behavioral symptoms that afflicts patients. Patients with depression or post-traumatic stress disorder (PTSD) show activity asymmetry between the two hemispheres of medial prefrontal cortex (mPFC). However, how the hemispheric activity asymmetry cause emotional disorders remains unclear. Here, we have revealed that the hemispheric asymmetry of mPFC is found in stressed mice that show depression-like behaviors. Their left hemisphere is depressed as measured by decreased neuronal firing. When the left mPFC is optically stimulated, their depression-like behaviors disappear. In resilient mice that show normal behaviors, the photoinhibition of left mPFC induce depression-like behaviors. From the analysis of microarray data in each mPFC hemispheres, we discovered that the genetic changes in the left cortices determines the adaptive behavior upon social defeat stress. Evidenced together with the neural activity, we conclude that the left mPFC plays a critical role in emotional change by stress and this signals hope that we can cure depression by modulating neural circuits using lights.