Date 2016-05-10 

■ TopicSmart Biomedical Nanomaterials for Translational Nanomedicines

■ Speaker : Prof. Sei Kwang Hahn, (Dept. of MSE, POSTECH)


■ Invitation : Prof. Yoon Sung Nam

■ Date & Time : May 10 (Tue), 16:00

■ Venue : KAIST Applied Engineering B/D(W1), Multimedia Lecture Hall (1st Floor)


■ AbstractNano-medicine is the term for the use of advanced bio- and nano-technologies for the development of innovative medicines. In this seminar, smart translational nanomedicines using biomedical nanomaterials will be presented for drug delivery and tissue engineering applications. The first part will cover real-time bioimaging of hyaluronic acid (HA) derivatives using quantum dots. HA derivatives with carboxyl group modification less than 25 mol% mainly accumulated in the liver, whereas highly modified HA derivatives evenly distributed in the body. On the basis of these findings, we successfully developed target specific HA - interferon a conjugate and HA - gold nanoparticle / interferon a complex for the treatment of hepatitis C virus infection. In the second part, smart hydrogels will be presented as artificial extracellular matrices (ECMs) for cell-based sensing and therapy. In situ supramolecularly assembled and modularly modified HA hydrogels were developed for genetically engineered mesenchymal stem cell (eMSC) therapy. In addition, optogenetic cells encapsulated in poly(ethylene glycol) hydrogels could be used to measure the nanotoxicity of cadmium-based quantum dots in vivo and to perform light-controlled diabetic therapy. Bioabsorbable polymer optical waveguide was also developed for deep-tissue photomedicine. Finally, we developed silicone hydrogels for a smart contact lens composed of biosensors, drug delivery systems, and power sources for the treatment of diabetes as a model disease. All these systems will be discussed in detail for further translational applications.