신소재공학과

Research Highlight

Flexible Drug Delivery Microdevice to Advance Precision Medicine 이미지1


(Schematic view of flexibe microdevice: The flexible drug delivery device for controlled release

fabricated via inorganic laser lift off.)





A KAIST research team has developed a flexible drug delivery device with controlled release for personalized medicine, blazing the path toward theragnosis.


Theragnosis, an emerging medical technology, is gaining attention as key factor to advance precision medicine for its featuring simultaneous diagnosis and therapeutics. Theragnosis devices including smart contact lenses and microneedle patches integrate physiological data sensors and drug delivery devices. The controlled drug delivery boasts fewer side-effects, uniform therapeutic results, and minimal dosages compared to oral ingestion. Recently, some research groups conducted in-human applications of controlled-release bulky microchips for osteoporosis treatment. However they failed to demonstrate successful human-friendly flexible drug delivery systems for controlled release.




For this microdevice, the team under Professor Daesoo Kim from the Department of Biological Science and Professor Keon Jae Lee from the Department of Materials Science and Engineering, fabricated a device on a rigid substrate and transferred a 50 µm-thick active drug delivery layer to the flexible substrate via inorganic laser lift off. The fabricated device shows mechanical flexibility while maintaining the capability of precise administration of exact dosages at desired times. The core technology is to produce a freestanding gold capping layer directly on top of the microreservoir with the drugs inside, which had been regarded as impossible in conventional microfabrication.




The developed flexible drug delivery system can be applied to smart contact lenses or the brain disease treatments by implanting them into cramped and corrugated organs. In addition, when powered wirelessly, it will represent a novel platform for personalized medicine. The team already proved through animal experimentation that treatment for brain epilepsy made progress by releasing anti-epileptic medication through the device.

 

Professor Lee believes the flexible microdevice will further expand the applications of smart contact lenses, therapeutic treatments for brain disease, and subcutaneous implantations for daily healthcare system. This study “Flexible Wireless Powered Drug Delivery System for Targeted Administration on Cerebral Cortex” was described in the June online issue of Nano Energy.

 

Flexible Drug Delivery Microdevice to Advance Precision Medicine 이미지2

(Photo: The flexible drug delivery device for contolled relase attached on a glass rod.)

No. Subject Author Date Views
Notice KAIST Introduces Faster and More Powerful Aqueous Hybrid Capacitor ADMINI 2018.11.13 6
Notice Crystal size of organic semiconductors can be controlled using inorganic polymer micropillar-based solution shearing system ADMINI 2018.11.06 64
Notice Mussel-Inspired Defect Engineering Enhances the Mechanical Strength of Graphene Fibers ADMINI 2018.11.06 40
Notice Flexible Piezoelectric Acoustic Sensors for Speaker Recognition ADMINI 2018.10.04 163
Notice Spray Coated Tactile Sensor on a 3-D Surface for Robotic Skin ADMINI 2018.10.04 149
Notice Levitating 2D Semiconductor for Better Performance ADMINI 2018.08.29 443
» Flexible Drug Delivery Microdevice to Advance Precision Medicine ADMINI 2018.08.14 476
43 A New Efficient Oxide Coating Technology to Improve Fuel Cells ADMINI 2018.08.03 571
42 A High-Performance and Cost Effective Hydrogen Sensor ADMINI 2018.08.03 473
41 KAIST Team Develops Flexible Blue Vertical Micro LEDs ADMINI 2018.06.26 705
40 Platinum Catalyst Has Price Lowed and Durability Doubled ADMINI 2018.06.26 758
39 Capillary Forces at Work for Lithium-Sulfur Batteries ADMINI 2018.06.26 651
38 New Material for Generating Energy-Efficient Spin Currents ADMINI 2018.06.26 522
37 Low-power, Flexible Memristor Circuit for Mobile and Wearable Devices ADMINI 2018.06.26 407
36 KAIST Develops Sodium Ion Batteries using Copper Sulfide ADMINI 2018.04.24 1163
35 Researchers develop flexible vertical micro LED file ADMINI 2018.02.07 1236
34 Lifespan of Fuel Cells Maximized using Small Amount of Metals file ADMINI 2018.01.21 1332
33 A New Spin Current Generating Material Developed file ADMINI 2017.12.21 1387
32 Professor Kim Sang Ouk of KAIST participated in editorship of GRAPHIN NEW MATERIALS file ADMINI 2017.10.23 1755
31 Pd nanowire array-based ultra-fast hydrogen gas sensor by using engineered nanofiltration of metal-organic framework file ADMINI 2017.09.27 1957