신소재공학과

Seminar

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Date 20180220

■ Title : Hydrogel-based tissue imaging:

            How materials science is revolutionizing neuroscience, biology, and medicine

 

■ Speaker : Prof. Jae-Byum Chang (Sungkyunkwan Univ.) 


■ Date and time : 20th of February, 2018 (Tue) 16:00 

 

■ Venue : Applied Engineering Department (W1-1) Room 2427 

 

■ Abstract :

Our understanding on human organs is very limited. Human organs are made of millions of cells and the molecular profiles of cells, such as numbers and sub-cellular locations of various biomolecules (proteins, mRNAs, DNAs, etc.) are precisely controlled over an entire organ. As a result, extracting the complete profiles of biological molecules within an entire organ is essential to understanding the molecular mechanisms of organ function. To achieve such goal, new optical imaging technique, which can image multiple molecular species with a single-molecule resolution over a large volume, is needed.

We recently discovered that we could physically magnify specimens by embedding them in a dense swellable polymer, anchoring key biomolecules to the polymer mesh, and adding water to swell the polymer, a process we call ‘expansion microscopy’1. Despite the high isotropy of the expansion process, the initial polymer recipe enabled just 4-4.5x expansion, or roughly 60-70 nm spatial resolution. Ideally it would be possible to improve the expansion chemistry so as to enable, ultimately, the imaging of membrane boundaries, as well as protein complexes. Here, we report on an iterative ExM (iExM) chemistry that can achieve ~20x physical magnification of mouse brain tissues, or 20-nm lateral resolution on conventional optical microscopes2. As with the first version of ExM, iExM-processed samples are optically clear. Thus, iExM may be useful for imaging nanoscale neuronal structures such as synaptic clefts over entire neural circuits in intact mammalian tissues. Brain circuit mapping using iterative ExM may open up a variety of insights into the underpinnings of behavior, cognition, and disease. In addition, as iExM can be applied to various organs, such as heart, liver, pancreas, lung, intestine, they could be a very useful tool to study and diagnose various diseases, such as cancers and cardiovascular diseases.


List of Articles
No. Category Subject Author Date Views
Notice Regular 9/18 (Tue) Prof. Seong Jun Kang (Kyung Hee Univ.) ADMINI 2018.09.17 13
Notice Regular 9/11 (Tue) Dr. Byeongdu Lee (Argonne National Laboratory) ADMINI 2018.09.07 97
Notice Regular 9/4 (Tue) Prof. Kibum Kang (Department of MSE, KAIST) ADMINI 2018.09.03 101
Notice Regular 8/28 (Tue) Prof. Kyung-Min Kim (Department of MSE, KAIST) ADMINI 2018.08.24 142
Notice Special 8/24 (Fri) Prof. Joel W. Ager III (UC Berkeley, Lawrence Berkeley National Laboratory) file ADMINI 2018.08.20 160
Notice Special 8/23 (Thu) Prof. Jeehwan Kim (MIT, USA) file ADMINI 2018.08.20 174
Notice Special 8/23 (Thu) Prof. YANGUANG LI (Soochow University) file ADMINI 2018.08.20 92
273 Regular 2015 The Fall Semester Seminar file TeamLeader 2015.03.04 18991
272 Special 2/25 (월) 홍승범박사 (Argonne National Laboratory) Administrator 2013.02.06 17980
271 Regular [공지] 2011년 가을학기 신소재공학과 정기세미나 안내 file Administrator 2011.11.04 15323
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267 Regular 5/15 (화) 조문호 교수 (연세대학교 신소재공학과) Administrator 2012.05.09 14003
266 Special [WCU-FS 사업단 세미나] 6/7 (화) 조정대 박사 (한국기계연구원) Administrator 2011.11.04 13553
265 Special 10/19 (수) Dr. Miso Kim (MIT) Administrator 2011.11.04 11795
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262 Regular 10/11 (화) 조성준 교수 (전남대학교 응용화학공학부 file Administrator 2011.11.04 11383
261 Regular 10/18 (화) 이윤정 교수 (한양대학교 WCU, 에너지공학과) file Administrator 2011.11.04 11357
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